Product Description
YBX1 polyclonal antibody is available at gentaur for next week delivery
Background: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro).
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: YBX1 polyclonal antibody detects endogenous levels of YBX1 protein.
W4BiowMW: ~ 49 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
A synthetic peptide of human YBX1.Alternative Name:
Nuclease-sensitive element-binding protein 1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB-1; YBX1; NSEP1; YB1Western blot analysis: Western blot analysis of extracts of various cells, using YBX1 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human lung cancer using YBX1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded human prostate using YBX1 antibody at dilution of 1:100 (40x lens).
Host: Rabbit
Swiss-Prot: P67809
"
