HUMAN CD Antigen designations

HUMAN CD Antigen designations (as of Workshop VI )
CD antigenCellular expressionMolecular weightFunctionsOther namesFamily relationships




Cortical thymocytes, Langerhans cells, Dendritic cells, B cells (CD1c), Intestinal epithelium (CD1d) 43-49 MHC class I-like molecule, associated with b2-microglobulin. May have specialised role in antigen presentation   Ig superfamily (IgSF)
CD2 T cells, thymocytes, NK cells 45-58 Adhesion molecule, binding CD58 (LFA-3). Can activate T cells T11, LFA-2 IgSF
CD2R Activated T cells 45-58 activation-dependent conformational form of CD2 T11-3 IgSF
CD3 Thymocytes, T cells g:25-28
Associated with the T cell antigen receptor. Required for cell surface expression of and signal transduction by TCR. T3 IgSF (gde) z/h related to FcR g chain
CD4 Thymocyte subsets, helper and inflammatory T cells (about two thirds of peripheral T cells), monocytes, macrophages 55 Coreceptor for MHC class II molecules. Binds lck on cytoplasmic face of membrane. Receptor for HIV-I and HIV-2 gp120. T4, L3T4 IgSF
CD5 Thymocytes, T cells, subset of B cells 67 Binds to CD72 T1, Ly1 Scavenger receptor
CD6 Thymocytes, T cells, B cell CLL 100-130 unknown. T12 Scavenger receptor
CD7 Pluripotential hematopoietic cells, thymocytes, T cells 40 unknown. Marker for T cell ALL and pluripotential stem cell leukemias   IgSF
CD8 Thymocyte subsets, cytotoxic T cells (about one third of peripheral T cells) a: 32-34
b: 32-34
Coreceptor for MHC class I molecules. Binds lck on cytoplasmic face of membrane T8, Lyt2,3 IgSF
CD9 Pre-B cells, eosinophils, basophils, platelets 22-27 possible role in platelet aggregation and activation   tetraspanning membrane protein
CD10 B and T cell precursors, bone marrow stromal cells 100 zinc metalloproteinase, marker for pre B ALL Neutral endopeptidase, Common Acute Lymphocytic Leukemia Antigen (CALLA)  
CD11a lymphocytes, granulocytes, monocytes and macrophages 180 aL subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1), ICAM-2 and ICAM-3 LFA-1  
CD11b myeloid and natural killer cells 170 aM subunit of integrin CR3 (associated with CD18) ; binds CD54, complement component iC3b and extracellular matrix proteins Mac-1  
CD11c myeloid cells 150 aX subunit of integrin CR4 (associated with CD18) ; binds fibrinogen CR4,
p150, 95
CDw12 monocytes, granulocytes, platelets 90-120 unknown    
CD13 myelomonocytic cells 150-170 zinc metalloproteinase aminopeptidase N  
CD14 myelomonocytic cells 53-55 receptor for complex of LPS and LPS binding protein (LBP)    

& CD15S

neutrophils, eosinophils, monocytes   branched pentasaccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM) Lewsi-x (Lex)  
CD15u sulphated CD15        

a & b

neutrophils, NK cells, macrophages 50-80 component of low affinity Fc receptor, FcgRIII, mediates phagocytosis and ADCC. FcgRIII IgSF
CDw17 neutrophils, monocytes, platelets   lactosyl ceramide, a cell surface glycosphingolipid    
CD18 Leukocytes 95 integrin b2 subunit, associates with CD11a,b and c.    
CD19 B cells 95 forms complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells   IgSF
CD20 B cells 33-37 possible role in regulating B cell activation   tetraspanning membrane protein
CD21 mature B cells, FDC 145 receptor for complement component C3d, EBV. With CD19 and CD81 forms coreceptor for B cells CR2 complement control protein (CCP) superfamily
CD22 mature B cells a: 130
b: 140
Adhesion of B cells to monocytes, T cells BL-CAM IgSF
CD23 mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets 45 low affinity receptor for IgE, ligand for CD19:CD21:CD81 coreceptor FceRII C-type lectin
CD24 B cells, granulocytes 35-45 unknown possible human homologue of mouse Heat Stable Antigen (HSA) or J11d.  
CD25 activated T cells, B cells, monocytes a:55
IL-2 receptor Tac a:CCP b: cytokine receptor superfamily
CD26 Activated B and T cells, macrophages 110 protease. Recently implicated in HIV entry into cells. Dipeptidyl peptidase IV  
CD27 Medullary thymocytes, T cells 50-55 unknown   NGF receptor superfamily
CD28 T cell subsets, activated B cells 44 Activation of naive T cells, receptor for costimulatory signal (signal 2) binds CD80 (B7-1) and B7-2 Tp44 IgSF
CD29 Leukocytes 130 Integrin b1 subunit, associates with CD49a in VLA-1 integrin    
CD30 Activated B and T cells 105-120 unknown Ki-1 NGF receptor superfamily
CD31 monocytes, platelets, granulocytes, B cells, endothelial cells 130-140 Possibly an adhesion molecule PECAM-1 IgSF
CDw32 Monocytes, granulocytes, B cells eosinophils 40 low affinity Fc receptor for aggregated Ig/immune complexes FcgRII IgSF
CD33 myeloid progenitor cells, monocytes 67 unknown   IgSF
CD34 hematopoietic precursors, capillary endothelium 105-120 Ligand for CD62 (L-selectin)    
CD35 Erythrocytes, B cells, monocytes, neutrophils, eosinophils, FDC 250 Complement receptor 1, binds C3B and C4b, mediates phagocytosis CR1 CCP superfamily
CD36 platelets, monocytes 88 unknown platelet GPIV  
CD37 mature B cells, mature T cells, myeloid cells 40-52 unknown   tetraspanning membrane protein
CD38 early B and T cells, activated T cells, germinal centre B cells, plasma cells 45 unknown    
CD39 activated B cells, activated NK cells, macrophages, dendritic cells 78 unknown, may mediate adhesion of B cells    
CD40 B cells, monocytes, dendritic cells 50 receptor for costimulatory signal for B cells, binds CD40 Ligand (T-BAM),   NGF receptor superfamily
CD40L (CD154) activated CD4 T cells 39 ligand for CD40, T-BAM TNF-like
CD41 platelets, megakaryocytes 125/22 dimer aIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor and thrombospondin    

      ,  b,



platelets, megakaryocytes a: 23
b: 135, 23
c: 22
d: 85
binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury a: GPIX
b: GPIba
c: GPIbb
d: GPV
CD43 leukocytes, except resting B cells 115-135 (neutrophils)
95-115 (T cells)
binds CD54 (ICAM-1) leukosialin, sialophorin  
CD44 leukocytes, erythrocytes 80-95 binds hyaluronic acid, mediates adhesion of leukocytes Hermes antigen, Pgp-1  
CD45 leukocytes 180-240 tyrosine phosphatase, augments signalling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below) Leukocyte common antigen (LCA), T200, B220  
CD45RO T cell subsets, B cell subsets, monocytes, macrophages 180 isoform of CD45 containing none of the A, B and C exons    
CD45RA B cells, T cell subsets (naive T cells) monocytes 205-220 isoforms of CD45 containing the A exon    
CD45RB T cell subsets, B cells, monocytes, macrophages, granulocytes 190-220 isoforms of CD45 containing the B exon T200  
CD45RC Restricted T200        
CD46 hematopoietic and non-hematopoietic nucleated cells 56/66 (splice variants) membrane cofactor protein, binds to C3b and C4b to permit their degradation by Factor I MCP CCP superfamily
CD47 all cells 47-52 unknown, associated with Rh blood group    
CD47R previously CDw149        
CD48 leukocytes 40-47 unknown Blast-1 IgSF
CD49a activated T cells, monocytes 210 a1 integrin, associates with CD29, binds collagen, laminin VLA-1  
CD49b B cells, monocyte, platelets 165 a2 integrin, associates with CD29, binds collagen, laminin VLA-2  
CD49c B cells 125 a3 integrin, associates with CD29, bindslaminin, fibronectin VLA-3  
CD49d B cells, thymocytes 150 a4 integrin, associates with CD29, binds fibronectin, PeyerÕs Patch HEV, VCAM-1 VLA-4  
CD49e memory T cells, monocytes, platelets 135, 25 dimer a5 integrin, associates with CD29, binds fibronectin VLA-5  
CD49f memory T cells, thymocytes, monocytes 120, 25 dimer a6integrin, associates with CD29, binds laminin VLA-6  
CD50 thymocytes, T cells, B cells,monocytes, granulocytes 130 unknown  ICAM3  
CD51 platelets, megakaryocytes 125,24 dimer av integrin, associates with CD61, binds vitronectin, von Willebrand factor, fibrinogen and thrombospondin vitronectin receptor  
CD52 thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes 21-28 unknown, target for antibodies used therapeutically to deplete T cells CAMPATH-1  
CD53 leukocytes 35-42 unknown MRC OX44 tetraspanning membrane protein
CD54 hematopoietic and non-hematopoietic cells 85-110 InterCellular Adhesion Molecule, (ICAM)-1 binds CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) integrins, receptor for rhinovirus ICAM-1 IgSF
CD55 hematopoietic and non-hematopoietic cells 60-70 Decay Accelerating Factor (DAF), binds C3b, disassembles C3/C5 convertase DAF CCP superfamily
CD56 NK cells 175-185 isoform of Neural Cell Adhesion Molecule (NCAM), adhesion molecule NKH-1 IgSF
CD57 NK cells subsets of T cells, B cells and monocytes   oligosaccharide, found on many cell surface glycoproteins HNK-1, Leu-7  
CD58 hematopoietic and non-hematopoietic cells 55-70 Leukocyte Function-associated Antigen-3 (LFA-3), binds CD2, adhesion molecule LFA-3 IgSF
CD59 hematopoietic and non-hematopoietic cells 19 binds comlement components C8 and C9, blocks assembly of membrane attack complex Protectin, Mac inhibitor  
CD60 T cell subsets, platelets, monocytes   oligosaccharide present on gangliosides    
CD60a GD3        
CD60b 9-O-acetyl-GD3        
CD60c 7-O-acetyl-GD3        
CD61 platelets, megakaryocytes, macrophages 105 integrin b3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin receptor)    
CD62E endothelium 140 endothelium leukocyte adhesion molecule (ELAM), bindssialyl-Lewis x, mediates rolling interaction of neutrophils on endothelium ELAM-1, E-selectin C type lectin
CD62L B cells, T cells, monocytes, NK cells 150 leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling interactions with endothelium LAM-1, L-selectin, LECAM-1 C type lectin
CD62P platelets, megakaryocytes, endothelium 140 adhesion molecule, binds sialyl Lewis x, mediates interaction of platelets with neutrophils, monocytes and rolling interaction of neutrophils on endothelium P-selectin, PADGEM C type lectin
CD63 activated platelets, monocytes, macrophages 53 unknown, is lysosomal membrane protein translocated to cell surface after activation   tetraspanning membrane protein
CD64 monocytes, macrophages 72 hign affinity receptor for IgG FcgRI IgSF
  myeloid cells   oligosaccharide component of a ceramide dodecasaccharide    
CD65 Ceramide dodecasaccharide 4c        
CD66a neutrophils 160-180 unknown, member of carcinoembryonic antigen (CEA) family (see below) biliary glycoprotein-1 (BGP-1) IgSF
CD66b granulocytes 95-100 unknown, member of carcinoembryonic antigen (CEA) family previously CD67 IgSF
CD66c neutrophils, colon carcinoma 90 unknown, member of carcinoembryonic antigen (CEA) family Nonspecific Crossreacting Antigen (NCA) IgSF
CD66d neutrophils 30 unknown, member of carcinoembryonic antigen (CEA) family   IgSF
CD66e adult colon epithelium, colon carcinoma 180-200 unknown, member of carcinoembryonic antigen (CEA) family CarcinoEmbryonic Antigen (CEA) IgSF
CD66f Pregnancy specific glycoprotein        
CD68 monocytes, macrophages, neutrophils, basophils, large lymphocytes 110 unknown macrosialin  
CD69 activated B cells, activated T cells, activated macrophages, activated NK cells 28, 32 homodimer unknown, early activation antigen Activation Inducer Molecule (AIM)  
CD70 activated B cells, activated T cells, macrophages 75,95,170 unknown Ki-24  
CD71 activated leukocytes 90-95 homodimer transferrin receptor T9  
CD72 B cells 42 homodimer unknown, ligand for CD5 Lyb-2 C type lectin
CD73 B cell subsets, T cell subsets 69 ecto-5Õ-nucleotidase, dephosphorylates nucleotides to allow nucleoside uptake    
CD74 B cells, macrophages, monocytes, MHC class II positive cells 33,35,41,43 (alternate initiation and splicing) MHC class II associated Invariant chain Ii, Ig  
CD75 mature B cells, T cell subsets   unknown, possibly oligosaccharide, dependent on sialylation    




  unknown, possibly oligosaccharide, dependent on sialylation    
CD77 germinal center B cells   unknown, Globotriaocylceramide (Gb3), Pk blood group  


B cells   unknown Ba  


B cells a: 32-33
b: 37-39
components of B cell antigen receptor analogous to CD3, required for cell surface expression and signal transduction Iga, Igb IgSF
CD80 B cell subset 60 costimulator, ligand for CD28 and CTLA-4 B7 (now B7-1), BB1 IgSF
CD81 lymphocytes 26 associates with CD19, CD21 to form B cell coreceptor Target of AntiProliferative Antibody (TAPA-1) tetraspanning membrane protein
CD82 leukocytes 50-53 unknown R2 tetraspanning membrane protein
CD83 Activated B cells, activated T cells, circulating dendritic cells (veil cells) 43   HB15  
CDw84 monocytes, platelets, circulating B cells 73   GR6  
CD85 ILT/LIR family        
CD86 monocytes, activated B cells 80   FUN-1, GR65  
CD87 granulocytes, monocytes, macrophages, activated T cells 50-65 Urokinase plasminogen activator receptor UPA-R  
CD88 polymorphonuclear leukocytes, macrophages, mast cells 40 Receptor for complement component C5a C5aR rhodopsin superfamily
CD89 monocytes, macrophages, granulocytes, neutrophils, B cell subsets, T cell subsets 50-70 IgA receptor FcaR IgSF
CD90 CD34+ prothymocytes (human) thymocytes, T cells (mouse) 18 unknown Thy-1 IgSF
CD91 monocytes 600 a2 macroglobulin receptor see lipoprotein unknown  
CDw92 neutrophils, monocytes, platelets, endothelium 70 unknown GR9  
CD93 neutrophils, monocytes, endothelium 120 unknown GR11  
CD94 T cell subsets, NK cells 43 unknown KP43  
CD95 wide variety of cell lines in vivodistribution uncertain 43 binds TNF-like ligand, induces apoptosis Apo-1, Fas NGF receptor superfamily
CD96 activated T cells 160 Unknown T cell ACTivation Increased Late Expression (TACTILE)  
CD97 activated cells 74, 80, 90 unknown GR1  
CD98 T cells, B cells, NK cells, granulocytes, all human cell lines 80, 40 heterodimer unknown 4F2  
CD99 Peripheral blood lymphocytes, thymocytes 32 Unknown MIC2, E2  
CD100 Broad expression on haematopoietic cells 150 unknown GR3  
CD101 Granulocytes, macrophages 140 Unknown BPC#4,BB27;BA27  
CD102 Resting lymphocytes, monocytes, strongest on vascular endothelial cells 55-65 binds CD11a/CD18 (LFA-1) but not CD11b/CD18 (Mac-1) ICAM-2 IgSF
CD103 Intraepithelial lymphocytes, 2-6% of peripheral blood lymphocytes 150,25 aE integrin HML-1, a6, aE integrin  
CD104 Epithelia, Schwann cells, some tumour cells 220 b4 integrin b4, b4 integrin  
CD105 Endothelial cells, bone marrow cell subset, in vitro activated macrophages 95, homodimer unknown, possibly ligand for an integrin Endoglin  
CD106 Endothelial cells 100,110 Adhesion molecule, ligand for VLA-4 VCAM-1 IgSF
CD107a Activated platelets 110 Unknown, is lysosomal membrane protein translocated to the cell surface after activation Lysosomal Associated Membrane Protein-1 (LAMP-1)  
CD107b activated platelets 120 Unknown, is lysosomal membrane protein translocated to the cell surface after activation LAMP-2  
CD108 Activated T cells in spleen, some stromal cells 80 Unknown GR2  
CD109 Activated T cells, platelets, endothelial cells 170/50 Unknown Platelet activation factor, GR56  
CD110 Platelets     NPL, TPO R  
CD111 Myeloid Cells     PRR1/Nectin1  
CD112 Myeloid Cells     PRR2