Product Description
UIMC1 polyclonal antibody is available at gentaur for next week delivery
Background: Receptor-associated protein 80 (RAP80), also known as Ubiquitin interaction motif-containing protein 1 (UIMC1) or Retinoid X receptor-interacting protein 110 (RXRIP110), is a 719 amino acid protein. Acting as a transcription repressor, RAP80 interacts with GCNF, thereby blocking GCNF interaction with the corepressor N-CoR. Localized to the nucleus, RAP80 is phosphorylated upon DNA damage. RAP80 contains two nuclear localization signals and one UIM (ubiquitin-interacting motif) repeat in the N-terminus, while the C-terminus contains two zinc fingers, a third nuclear localization signal and a potential PEST sequence. RAP80 is expressed as four isoforms produced by alternative splicing and is present in thymus, testis, heart and ovary.
Applications: WB IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: UIMC1 polyclonal antibody detects endogenous levels of UIMC1 protein.
W4BiowMW: ~ 60, 80, 120kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human UIMC1.Alternative Name:
BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1; UIMC1; RAP80, RXRIP110Western blot analysis: Immunofluorescence analysis of GFP-RNF168 trangenic U2OS cell using UIMC1 antibody. Green:GFP-RNF168 fusion protein expression for DNA damage marker.Blue: DAPI for nuclear staining.RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.
Immunohistochemistry: Immunofluorescence analysis of U20S cell using UIMC1 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q96RL1
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