Product Description
UBE2O polyclonal antibody is available at gentaur for next week delivery
Background: UBE20 (ubiquitin-conjugating enzyme E2O), also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.
Applications: WB IP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: UBE2O polyclonal antibody detects endogenous levels of UBE2O protein.
W4BiowMW: ~ 200 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant protein of human UBE2O.Alternative Name:
KIAA1734; Ubiquitin-protein ligase O; (E3-independent) E2 ubiquitin-conjugating enzymeWestern blot analysis: Western blot analysis of extracts of various cells, using UBE2O antibody.
Immunohistochemistry: Western blot analysis of extracts from normal (control) and UBE2O knockout (KO) HeLa cells, using UBE2O antibody.
Immunofluorescence analysis: Immunoprecipitation analysis of 200ug extracts of A-431 cells using 3ug UBE2O antibody.
Host: Rabbit
Swiss-Prot: Q9C0C9
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