Product Description
TWIST1 (M1) polyclonal antibody is available at gentaur for next week delivery
Background: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TWIST1 (M1) polyclonal antibody detects endogenous levels of TWIST1 protein.
W4BiowMW: ~ 22 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
A synthetic peptide corresponding to amino acids 1-50 of Human TWIST1.Alternative Name:
Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; BHLHA38; TWISTWestern blot analysis: Western blot (WB) analysis of TWIST1 (M1) polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate(40ug) Lane2:RAW264.7 whole cell lysate(40ug)
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q15672
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