Product Description
TRMT1 polyclonal antibody is available at gentaur for next week delivery
Background: N(2),N(2)-dimethylguanosine tRNA methyltransferase, also known as TRMT1 or tRNA(guanine-26,N(2)-N(2)) methyltransferase, is a 659 amino acid enzyme that is responsible for tRNA modifications in eukaryotes. Using S-adenosyl-L-methionine as a methyl donor, TRMT1 dimethylates a single guanine residue at position 26 of tRNA. TRMT1, which was initially identified in yeast and C. elegans, has a 26% and 31% sequence identity to its yeast and C. elegans homologs, respectively. There are two isoforms of TRMT1 produced by alternative splicing events. The TRMT1 gene maps to chromosome 19p13.13 and mutations in this gene lead to abrogated enzyme activity and a decrease in protein levels.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TRMT1 polyclonal antibody detects endogenous levels of TRMT1 protein.
W4BiowMW: ~ 90 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant protein of human TRMT1.Alternative Name:
TRM1; tRNA (guanine(26)-N(2))-dimethyltransferaseWestern blot analysis: Immunohistochemistry of paraffin-embedded human lung cancer using TRMT1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human gastric using TRMT1 antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q9NXH9
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