Product Description
TPH1 (Phospho-S58) polyclonal antibody is available at gentaur for next week delivery
Background: Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TPH1 (Phospho-S58) polyclonal antibody detects endogenous levels of TPH1 protein only when phosphorylated at Ser58.
W4BiowMW: ~ 51 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic phosphopeptide derived from human TPH1 around the phosphorylation site of Serine 58.Alternative Name:
Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; TPH1; TPH; TPRH; TRPHWestern blot analysis: Western blot (WB) analysis of TPH1 (Phospho-S58) polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:THP-1 whole cell lysate LaneC:MCF-7 whole cell lysate LaneD:SGC7901 whole cell lysate
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P17752
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