Product Description
TNFAIP6 polyclonal antibody is available at gentaur for next week delivery
Background: The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNFα and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNFα, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-α-inhibitor (IαI)). TSG-6 potentiates the inhibitory effect of lαl on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and lαl can modulate the protease network and thus inhibit inflammation.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TNFAIP6 polyclonal antibody detects endogenous levels of TNFAIP6 protein.
W4BiowMW: ~ 40 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human TNFAIP6.Alternative Name:
Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6; TNFAIP6; TSG6Western blot analysis: Immunohistochemistry of paraffin-embedded human gastric using TNFAIP6 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry: Immunohistochemistry of paraffin-embedded rat kidney using TNFAIP6 antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded mouse heart using TNFAIP6 antibody at dilution of 1:100 (x40 lens).
Host: Rabbit
Swiss-Prot: P98066
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