TAB1 (Phospho-S438) polyclonal antibody

Product Description

TAB1 (Phospho-S438) polyclonal antibody is available at gentaur for next week delivery

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported

Applications:  WB

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  TAB1 (Phospho-S438) polyclonal antibody detects endogenous levels of TAB1 protein only when phosphorylated at Ser438.

W4BiowMW:  ~ 60 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Synthetic phosphopeptide derived from human TAB1 around the phosphorylation site of Serine 438.

Alternative Name:

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1; TAB1; MAP3K7IP1

Western blot analysis:  Western blot (WB) analysis of TAB1 (Phospho-S438) polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:HEK293T whole cell lysate LaneC:MCF-7 whole cell lysate LaneD:The Eye tissue lysate of Mouse LaneE:The Brain tissue lysate of Mouse LaneF:The Brain tissue lysate of Rat

Immunohistochemistry:

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: Q15750

 

 

 

 

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