Product Description
SMC 1 (phospho-S957) polyclonal antibody is available at gentaur for next week delivery
Background: The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) along with SMC3 (also designated HCAP for human chromosome-associated protein or Bama-can), and SMC2 (also designated hCAP-E) along with SMC4 (also designated hCAP-C). The SMC1/SMC3 complex is required for metaphase progression in mitotic cells and functions independently of the SMC2/SMC4 complex during the cell cycle. SMC1 is ubiqitiously expressed in various human tissues, including thymus, testis and colon. SMC3 is expressed as a nuclear protein in the colon, but can also occur as a secreted proteoglycan (called Bamacan) expressed in testis and brain. Bamacan contains several glycosylation sites and is thought to play a role in basement membrane physiology.
Applications: WB IHC IF IP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-Smc1(S957) polyclonal antibody detects endogenous levels of Smc1 protein only when phosphorylated at Ser957.
W4BiowMW: ~ 160 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic phosphopeptide derived from human SMC 1 around the phosphorylation site of Serine 957.Alternative Name:
Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8; SMC1A; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1Western blot analysis: Western blot analysis of extracts of various cell lines, using SMC 1 (phospho-S957) polyclonal antibody.
Immunohistochemistry: Immunoprecipitation analysis of 200ug extracts of HeLa cells, using 3 ug SMC 1 (phospho-S957) polyclonal antibody.
Immunofluorescence analysis: Immunofluorescence analysis of U2OS cells, using SMC 1 (phospho-S957) polyclonal antibody
Host: Rabbit
Swiss-Prot: Q14683
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