Product Description
SAFB polyclonal antibody is available at gentaur for next week delivery
Background: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SAFB polyclonal antibody detects endogenous levels of SAFB protein.
W4BiowMW: 130kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
A synthetic peptide of human SAFBAlternative Name:
HSP27 estrogen response element-TATA box-binding protein; HAP; HET; SAFB1; SAF-B1Western blot analysis: Immunofluorescence analysis of U-2 OS cells using SAFB antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded rat liver using SAFB antibody.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q15424
"
