Product Description
RUNX3 polyclonal antibody is available at gentaur for next week delivery
Background: RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX3 is expressed in cells of hematopoietic origin, including myeloid and B-cell lines and spleen. By playing a role in controlling the growth and differentiation of gastric epithelial cells, RUNX3 is a strong candidate as a gastric cancer tumor suppressor. Specifically, hypermethylation inactivates the gene encoding RUNX3. The detection of hypermethylation at multiple regions within the RUNX3 CpG island may aid in the diagnosis and risk assessment of gastric cancer.
Applications: WB IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: RUNX3 polyclonal antibody detects endogenous levels of RUNX3 protein.
W4BiowMW: ~ 44kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human RUNX3.Alternative Name:
Runt-related transcription factor 3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; RUNX3; AML2; CBFA3; PEBP2A3Western blot analysis: Immunofluorescence analysis of MCF7 cell using RUNX3 antibody. Blue: DAPI for nuclear staining.
Immunohistochemistry: Western blot analysis of extracts of U-251MG cells, using RUNX3 antibody.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q13761
"
