RASGRP1 polyclonal antibody

Product Description

RASGRP1 polyclonal antibody is available at gentaur for next week delivery

Background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Applications:  WB

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  RASGRP1 polyclonal antibody detects endogenous levels of RASGRP1 protein.

W4BiowMW:  ~ 90 kDa

Reactivity: Human

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Recombinant protein of human RASGRP1

Alternative Name:

V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII;

Western blot analysis:  Western blot analysis of extracts of various cells, using RASGRP1 antibody.

Immunohistochemistry:

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: O95267

 

 

 

 

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