RASA4 polyclonal antibody

Product Description

RASA4 polyclonal antibody is available at gentaur for next week delivery

Background: RASA4 (ras GTPase-activating protein 4) is an 803 amino acid member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogenactivated protein kinase pathway in response to Ca2+. Stimuli that increase intracellular Ca2+ levels result in the translocation of the RASA4 protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth and differentiation. Containing 21 exons and spanning 35 kb of genomic DNA, RASA4 includes one Btk-type zinc finger, two C2 domains, one PH domain and one Ras-GAP domain.

Applications:  WB

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  RASA4 polyclonal antibody detects endogenous levels of RASA4 protein.

W4BiowMW:  ~ 85, 90 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

A synthetic peptide corresponding to residues in Human RASA4.

Alternative Name:

Ras GTPase-activating protein 4; Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2; CAPRI; GAPL; KIAA0538

Western blot analysis:  Western blot (WB) analysis of RASA4 (F157) pAb at 1:500 dilution Lane1:3T3-L1 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug)

Immunohistochemistry:

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: O43374

 

 

 

 

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