Product Description
PRKG1 polyclonal antibody is available at gentaur for next week delivery
Background: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PRKG1 polyclonal antibody detects endogenous levels of PRKG1 protein.
W4BiowMW: ~ 65 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human PRKG1.Alternative Name:
cGK 1; cGK1; cGKI alpha; CGKI; cGKI beta; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; DKFZp686K042; FLJ36117; KGP1_HUMAN; KGPB; MGC71944; pkg; PRKG1; PRKG1B; PRKGR1A; PRKGR1B;Western blot analysis: Western blot (WB) analysis of PRKG1 polyclonal antibody
Immunohistochemistry: Immunohistochemistry (IHC) analysis of PRKG1 polyclonal antibody in paraffin-embedded Rat Lung tissue.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q13976
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