Product Description
PML polyclonal antibody is available at gentaur for next week delivery
Background: The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal trans-location of the retinoic acid receptor α (RARα) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RARα chimeric protein. Myeloid precursor cells expressing the PML/ RARα chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PML polyclonal antibody detects endogenous levels of PML protein.
W4BiowMW: ~ 70-130 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human PML.Alternative Name:
Protein PML; Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19; MYL; PP8675; RNF71; TRIM19Western blot analysis: WesternBlot (WB) analysis of PML polyclonal antibody in extracts from Hela cells.
Immunohistochemistry: Immunohistochemistry (IHC) analysis of PML pAb in paraffin-embedded Human Thyroid Cancer tissue.
Immunofluorescence analysis: Immunofluorescence analysis of Hela cells, using PML polyclonal antibody
Host: Rabbit
Swiss-Prot: P29590
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