Product Description
PHIP polyclonal antibody is available at gentaur for next week delivery
Background: PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary β cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing β cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PHIP polyclonal antibody detects endogenous levels of PHIP protein.
W4BiowMW: ~ 250kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human PHIP.Alternative Name:
PH-interacting protein; PHIP; IRS-1 PH domain-binding protein; WD repeat-containing protein 11; PHIP; WDR11Western blot analysis: Immunofluorescence analysis of MCF7 cell using PHIP antibody.
Immunohistochemistry: Western blot analysis of extracts of various cell lines, using PHIP antibody.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q8WWQ0
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