Product Description
p53 polyclonal antibody is available at gentaur for next week delivery
Background: p53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p53 polyclonal antibody detects endogenous levels of p53 protein.
W4BiowMW: ~ 53 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human p53.Alternative Name:
Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53; P53Western blot analysis: WesternBlot (WB) analysis of p53 polyclonal antibody.
Immunohistochemistry: Immunohistochemistry (IHC) analysis of p53 pAb in paraffin-embedded Endometrial cancer tissue.
Immunofluorescence analysis: Immunofluorescence analysis of A549 cells, using p53 polyclonal antibody
Host: Rabbit
Swiss-Prot: P04637
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