p130 Cas (V404) polyclonal antibody

Product Description

p130 Cas (V404) polyclonal antibody is available at gentaur for next week delivery

Background: The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.

Applications:  WB IHC

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  p130 Cas (V404) polyclonal antibody detects endogenous levels of p130 Cas protein.

W4BiowMW:  ~ 130 kDa

Reactivity: Human,Mouse

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Synthetic peptide, corresponding to amino acids 380-430 of Human p130 Cas.

Alternative Name:

Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; Cas scaffolding protein family member 1; p130cas; BCAR1; CAS; CASS1; CRKAS

Western blot analysis:  Western blot (WB) analysis of BCAR1 pAb at 1:500 dilution Lane1:A549 whole cell lysate(20ug) Lane2:Beas-2B whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)

Immunohistochemistry: Immunohistochemistry (IHC) analyzes of p130 Cas (V404) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: P56945

 

 

 

 

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