Product Description
P-Cadherin (G78) polyclonal antibody is available at gentaur for next week delivery
Background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. R-cadherin (for retinal-cadherin, also designated cadherin-4), which was first identified in the retina of chicken, has been shown to be involved in the development of striated muscle and potentially epithelia in addition to its involvement in retinal development.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: P-Cadherin (G78) polyclonal antibody detects endogenous levels of P-Cadherin protein.
W4BiowMW: ~ 110 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to amino acids 45-90 of Human P-Cadherin.Alternative Name:
Placental cadherin; P-cadherin; CDH3; CDHPWestern blot analysis: Western blot (WB) analysis of P-cadherin (G78) pAb Antibody at 1:500 dilution Lane1:A375 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:Beas-2B whole cell lysate(40ug) Lane4:EC9706 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)
Immunohistochemistry: Immunohistochemistry (IHC) analyzes of P-cadherin (G78) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P22223
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