Product Description
OB-cadherin polyclonal antibody is available at gentaur for next week delivery
Background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin β, to regulate cadherin function. Two forms of OB-cadherin (for osteoblast-cadherin, also designated cadherin-11 or OSF-4) have been identified as OBcadherin- 1 and OB-cadherin-2. Both OB-cadherins are expressed in osteoblastic cell lines and low expression is also seen in lungs, testis and brain. OB-cadherin-2 has a truncated cytoplasmic domain.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: OB-cadherin polyclonal antibody detects endogenous levels of OB-cadherin protein.
W4BiowMW: ~ 120 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant protein of human CDH11.Alternative Name:
OB; CAD11; CDHOB; OSF-4;Western blot analysis: Western blot analysis of extract of various cells, using CDH11 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded mouse brain using CDH11 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P55287
"
