Product Description
Notch 2 polyclonal antibody is available at gentaur for next week delivery
Background: Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. Notch2 is a member of the Notch family and mutation in Notch2 is associated with Alagille syndrome.
Applications: WB IP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Notch 2 polyclonal antibody detects endogenous levels of Notch 2 protein.
W4BiowMW: ~ 110/260kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human Notch 2.Alternative Name:
Notch 2;Hn2;N2ECD;N2ICD;NOTCH2Western blot analysis: Western blot (WB) analysis of Notch 2 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:HepG2 whole cell lysate(40ug)
Immunohistochemistry: Immunoprecipitation - Notch 2 Polyclonal Antibody
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q04721
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