NLRP3 polyclonal antibody

Product Description

NLRP3 polyclonal antibody is available at gentaur for next week delivery

Background: Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Applications:  WB ICC/IF IHC IP FC

Purification&Purity: ProA affinity purified

Storage&Stability:  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity:  NLRP3 polyclonal antibody detects endogenous levels of NLRP3 protein.

W4BiowMW:  118/85 kDa

Reactivity: Human, Mouse, Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

recombinant protein

Alternative Name:

CLR1.1, NLRP3, AGTAVPRL, AII/AVP, Angiotensin/vasopressin receptor AII/AVP like, Angiotensin/vasopressin receptor AII/AVP-like, C1orf7, Caterpiller protein 1.1, CIAS 1, CIAS1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCAS, FCU, LRR and PYD domains-containing protein 3, Muckle-Wells syndrome, MWS, NACHT, NACHT LRR and PYD containing protein 3, NALP 3, NALP3, NALP3, NLRP3, PYPAF 1, PYPAF1, PYRIN containing APAF1 like protein 1, PYRIN-containing APAF1-like protein 1,

Western blot analysis:  Western blot analysis of NLRP3 on human lung tissue lysates.

Immunohistochemistry: ICC staining NLRP3 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Immunofluorescence analysis: ICC staining NLRP3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Host:  Rabbit

Swiss-Prot: Q96P20(Human) Q8R4B8(Mouse) EntrezGene:287362(Rat)

 

 

 

 

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