Product Description
NF2/Merlin polyclonal antibody is available at gentaur for next week delivery
Background: Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: NF2/Merlin polyclonal antibody detects endogenous levels of NF2/Merlin protein.
W4BiowMW: ~ 80kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human NF2/Merlin.Alternative Name:
Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; NF2; SCHWestern blot analysis: Western blot analysis of extracts of various cell lines, using NF2 antibody.
Immunohistochemistry: Western blot analysis of extracts from normal (control) and NF2 knockout (KO) HeLa cells, using NF2 antibody.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P35240
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