Product Description
NeuN polyclonal antibody is available at gentaur for next week delivery
Background: Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein that contains one RRM (RNA recognition motif) domain. Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events. Fox-3 is encoded by a gene located on human chromosome 17, which is comprised over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and LiFraumeni syndrome.
Applications: WB, IHC, IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: NeuN polyclonal antibody detects endogenous levels of NeuN protein.
W4BiowMW: ~ 50 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human NeuN.Alternative Name:
RNA binding protein fox-1 homolog 3; Fox-1 homolog C; Hexaribonucleotide-binding protein 3; Fox-3; Neuronal nuclei; NeuN; Rbfox3; D11Bwg0517e; Hrnbp3Western blot analysis: Western blot (WB) analysis of [KO Validated] NeuN pAb at 1:500 dilution Lane1:The brain tissue lysate of Mouse(40ug) Lane2:The brain tissue lysate of Rat(40ug)
Immunohistochemistry: Immunofluorescence analysis of MCF-7 cells using RBFOX3 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis: Immunofluorescence
Host: Rabbit
Swiss-Prot: Q8BIF2
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