Product Description
NEDD4 polyclonal antibody is available at gentaur for next week delivery
Background: NEDD4 is a 221 amino acid, Golgi-associated protein which contains three transmembrane domains in its carboxy-terminus and two PY motifs in its amino-terminus. NEDD4 may play a role in Golgi structure and function. It binds the WW domains of a number of NEDD4 family members called HECT-type E3 ubiquitin ligases. NEDD4 is strongly expressed in surviving neurons around an injury site, which suggests that ubiquitination may be a possible survival strategy and that NEDD4 may act as a neuroprotective protein. It may also have an effect on the function of Itch, another E3 ubiquitin ligase. Expression of NEDD4 and its association with Itch may be promoted by T cell activation.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: NEDD4 polyclonal antibody detects endogenous levels of NEDD4 protein.
W4BiowMW: ~ 120 kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant protein of human NEDD4.Alternative Name:
NEDD-4; NEDD4; KIAA0093; NEDD4-1; PIG53Western blot analysis: Western blot analysis of extracts of various cell lines, using NEDD4 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human prostate using NEDD4 antibody at dilution of 1:200 (40x lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded human gastric using NEDD4 antibody at dilution of 1:200 (40x lens).
Host: Rabbit
Swiss-Prot: P46934
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