Product Description
MUC6 polyclonal antibody is available at gentaur for next week delivery
Background: Mucin 6 (also designated MUC 6 and gastricmucin) is a large glycoprotein that plays amajor role in the protection of the gastrointestinal tract. MUC6 carries GlcNAcα1→4Galβ→R structures, indicating thatα1, 4-N-acetylglucosaminyltransferase isimportant to the formation of the mucous glycoproteinsin vivo. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileumand rightcolon. In gastriccancer, Mucin 6 has an altered expression. In normalstomach, Mucin 6 apomucin is associated with Lewistype 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deepermucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation. Mucin 6mRNA is expressed transientlyin the nephrogeniczone of the kidneyin the early mid-trimester of development, and Mucin 6 glycoprotein is expressed in the epithelium of ureteric buds and collecting ducts, but absent fromadultkidney. Proliferating bile ductularcells express Mucin 6 apomucin in diseased liver, especially in chronicviral hepatitiswith active necroinflammation,suggesting that this secreted mucin acts as a cytoprotective agent and represents a phenotype of reactive biliary epithelium in chronicviral hepatitis.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MUC6 polyclonal antibody detects endogenous levels of MUC6 protein.
W4BiowMW: ~ 270 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
A synthetic peptide corresponding to residues in Human MUC6.Alternative Name:
Mucin-6; MUC-6; Gastric mucin-6; MUC6Western blot analysis: Western blot (WB) analysis of MUC6 pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:Aml-12 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug) Lane4:A2780 whole cell lysate(40ug) Lane5:The Fallopian tube tissue lysate of Mouse(40ug) Lane6:HepG2 whole cell lysate (40ug)
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q6W4X9
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