MSR1 polyclonal antibody

Product Description

MSR1 polyclonal antibody is available at gentaur for next week delivery

Background: The macrophage class A scavenger receptor (SR-A) mediates the uptake of modified low density lipoprotein (LDL). The gene encoding human SR-A maps to chromosome 8 and gives rise to two alternatively spliced isoforms, type I and II (SR-AI and SR-AII), which were originally cloned from the phorbol ester-treated human monocytic cell line THP-1. Both isoforms contain six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), alpha-helical coiled-coil (IV), collagen-like (V) and a type-specific C-terminal (VI)). Domain IV is essential for the trimerization of SR-A, whereas domain V is essential for the wide range of ligand recognition. SR-A is expressed in liver, placenta and brain. Both SR-AI and SR-AII mediate the uptake of LDLs in atherosclerotic lesions. A third isoform,

Applications:  WB IF

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  MSR1 polyclonal antibody detects endogenous levels of MSR1 protein.

W4BiowMW:  ~ 63 kDa

Reactivity: Human,Mouse

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Recombinant full length Human MSR1.

Alternative Name:

Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD204; MSR1; SCARA1

Western blot analysis:  Western blot analysis of extracts of various cell lines, using MSR1 antibody.

Immunohistochemistry:

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: P21757

 

 

 

 

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