Product Description
MMRN1 polyclonal antibody is available at gentaur for next week delivery
Background: Multimerin-1, also known as MMRN1, EMILIN-4 or ECM (endothelial cell multimerin), is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MMRN1 polyclonal antibody detects endogenous levels of MMRN1 protein.
W4BiowMW: ~ 180 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human MMRN1.Alternative Name:
Multimerin-1; EMILIN-4; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; Endothelial cell multimerin; p-155; p155; MMRN1; ECM; EMILIN4; GPIA*; MMRNWestern blot analysis: Immunohistochemistry of paraffin-embedded human lung using MMRN1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry: Immunofluorescence analysis of U2OS cell using MMRN1 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q13201
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