Product Description
MMP-11 polyclonal antibody is available at gentaur for next week delivery
Background: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or taphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin- 1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and it is expressed at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MMP-11 polyclonal antibody detects endogenous levels of MMP-11 protein.
W4BiowMW: ~ 60 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human MMP-11.Alternative Name:
Stromelysin-3; Stromelysin 3; Stromelysin3; SL-3; ST3; Matrix metalloproteinase-11; MMP-11; MMP11; STMY3Western blot analysis: Western blot analysis of MMP-11 polyclonal antibody
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P24347
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