Product Description
MKK5 (Phospho-S311) polyclonal antibody is available at gentaur for next week delivery
Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MKK5 (Phospho-S311) polyclonal antibody detects endogenous levels of MKK5 protein only when phosphorylated at Ser311.
W4BiowMW: ~ 50 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic phosphopeptide derived from human MKK5 around the phosphorylation site of Serine 311.Alternative Name:
Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5; MAP2K5; MEK5, MKK5, PRKMK5Western blot analysis: Western blot (WB) analysis of MKK5 (Phospho-S311) polyclonal antibody at 1:500 dilution LaneA:The Heart tissue lysate of Mouse LaneB:The Heart tissue lysate of Rat LaneC:H1792 whole cell lysate LaneD:MCF-7 whole cell lysate
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q13163
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