Product Description
MDC1 polyclonal antibody is available at gentaur for next week delivery
Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MDC1 polyclonal antibody detects endogenous levels of MDC1 protein.
W4BiowMW: ~ 270 kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant protein of human MDC1.Alternative Name:
NFBD1;Western blot analysis: Western blot analysis of extracts of various cell lines, using MDC1 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human lung cancer using MDC1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded human colon carcinoma using MDC1 antibody at dilution of 1:100 (40x lens).
Host: Rabbit
Swiss-Prot: Q14676
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