Product Description
MB21D1 polyclonal antibody is available at gentaur for next week delivery
Background: cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.
Applications: ELISA WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MB21D1 polyclonal antibody detects endogenous levels of MB21D1 protein.
W4BiowMW: ~ 59 kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
A synthetic peptide of human MB21D1.Alternative Name:
cGAS; h-cGAS; C6orf150Western blot analysis: Western blot analysis of extracts of various cell lines, using MB21D1 antibody. Lane1:HT-29 whole cell lysate(40ug) Lane2:Lovo whole cell lysate(40ug)
Immunohistochemistry: Immunohistochemistry of paraffin-embedded Human liver cancer tissue using MB21D1 antibody at dilution of 1:20 (x40 lens).
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q8N884
"
