Product Description
MANF polyclonal antibody is available at gentaur for next week delivery
Background: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Applications: WB IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MANF polyclonal antibody detects endogenous levels of MANF protein.
W4BiowMW: ~ 16kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human MANF.Alternative Name:
Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET; MANF; ARMET, ARPWestern blot analysis: Western blot analysis of extracts of various cell lines, using MANF Antibody.
Immunohistochemistry: Immunofluorescence analysis of U2OS cells using MANF antibody.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P55145
"
