Product Description
LRP5 polyclonal antibody is available at gentaur for next week delivery
Background: LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain (1). They function as co-receptors for Wnt and are required for the canonical Wnt/β-catenin signaling pathway (2,3). LRP5 and LRP6 are highly homologous and have redundant roles during development (4,5). The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins (6,7). Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 (8-10). Phosphorylated LRP6 recruits axin to the membrane and presumably activates β-catenin signaling (8-10).LRP5 is involved in the regulation of bone homeostasis. Mutations and polymorphisms in LPR5 are associated with bone diseases like osteoporosis-pseudoglioma syndrome and high-bone-mass disorders (11-13). In addition, mutations in LRP5 are found in patients with hyperparathyroid tumor and breast cancer (14,15).
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: LRP5 polyclonal antibody detects endogenous levels of LRP5 protein.
W4BiowMW: ~ 150 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant protein of human LRP5.Alternative Name:
LRP5;BMND1;EVR1;EVR4;HBM;LR3;LRP7;OPPG;OPS;OPTA1;VBCH2;Western blot analysis: Western blot analysis of extracts of various tissues, using LRP5 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human liver using LRP5 antibody at dilution of 1:200 (40x lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded human prostate using LRP5 antibody at dilution of 1:200 (40x lens).
Host: Rabbit
Swiss-Prot: O75197
"
