Product Description
LRAT polyclonal antibody is available at gentaur for next week delivery
Background: Lecithin retinol acyltransferase (LRAT) is a membrane bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A which generates all-trans-retinyl esters (tREs) in the liver, some extrahepatic tissues, such as the lung, and retinal pigmented epithelium. LRAT can also exchange palmitoyl groups between RPE65, a tRE binding protein essential for vision, and tREs, which is important for the operation of the visual pathway. LRAT is essential for the dietary mobilization, transport, and storage of vitamin A as well as the synthesis of the visual pigment chromophore. LRAT monomers interact in membranes to form homodimers through disulfide bond formation. A loss of LRAT correlates with an early onset severe retinal dystrophy and severe retinyl ester deprivation, while a reduction in LRAT expression may be associated with invasive bladder cancer.
Applications: WB IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: LRAT polyclonal antibody detects endogenous levels of LRAT protein.
W4BiowMW: ~ 25-55kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human LRAT.Alternative Name:
Lecithin retinol acyltransferase; Phosphatidylcholine--retinol O-acyltransferase; Phosphatidylcholine-retinol O-acyltransferaseWestern blot analysis: Western blot analysis of extracts of various cell lines, using Lrat antibody.
Immunohistochemistry: Immunofluorescence analysis of MCF7 cells using LRAT antibody.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: O95237
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