Lamin A/C (phospho-S22) polyclonal antibody

Product Description

Lamin A/C (phospho-S22) polyclonal antibody is available at gentaur for next week delivery

Background: Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Applications:  WB IP

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  Lamin A/C (phospho-S22) polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser22.

W4BiowMW:  ~ 69, 78 kDa

Reactivity: Human,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

A phospho specific peptide corresponding to residues surrounding S22 of human LMNA

Alternative Name:

Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Western blot analysis:  Western blot analysis of extracts of various cell lines, using Phospho-LMNA-S22 antibody. Lane1:A549 whole cell lysate(40ug) Lane2:L02 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug)

Immunohistochemistry: Immunoprecipitation analysis of 200ug extracts of HeLa cells, using 3 ug Lamin A/C (phospho-S22) polyclonal antibody.

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: P02545

 

 

 

 

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