Product Description
IRF2 polyclonal antibody is available at gentaur for next week delivery
Background: Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 (the 48 kDa component of the ISGF-3 complex) and IFN consensus sequence-binding protein (ICSBP).
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IRF2 polyclonal antibody detects endogenous levels of IRF2 protein.
W4BiowMW: ~ 39kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human IRF2.Alternative Name:
IRF-2; IRF2; Interferon regulatory factor 2Western blot analysis: Western blot analysis of extracts of various cell lines, using IRF2 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded rat heart using IRF2 antibody at dilution of 1:200 (400x lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded rat brain using IRF2 antibody at dilution of 1:200 (400x lens).
Host: Rabbit
Swiss-Prot: P14316
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