Product Description
Integrin β1 (Y783) polyclonal antibody is available at gentaur for next week delivery
Background: Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ITGB1 (Y783) polyclonal antibody detects endogenous levels of ITGB1 protein.
W4BiowMW: ~ 115 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to amino acids 741-790 of Human Integrin β1.Alternative Name:
Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD29; ITGB1; FNRB; MDF2; MSK12Western blot analysis: Western blot (WB) analysis of ITGB1 pAb at 1:500 dilution Lane1:U-87MG whole cell lysate(40ug) Lane2:A375 whole cell lysate(40ug) Lane3:The Skin tissue lysate of Rat(40ug) Lane4:CT26 whole cell lysate(40ug)
Immunohistochemistry: Immunohistochemistry (IHC) analyzes of Integrin β1 (Y783) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P05556
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