Product Description
IL3RA polyclonal antibody is available at gentaur for next week delivery
Background: IL3RA/CD123 is the alpha subunit of an IL-3 receptor that also contains the common beta chain (βc) shared with receptors for other cytokines. IL3RA/CD123 alone binds to IL-3 with high specificity but low affinity and it does not transduce intracellular signaling, while βc alone does not bind to IL-3 appreciably. Together, IL3RA/CD123 and βc form the functional high-affinity receptor for IL-3. IL3RA/CD123 is mainly expressed on the hematopoietic progenitor cells, primarily the granulocytic and monocytic linages . IL3RA/CD123 is highly expressed on leukemic stem cells in the majority of AML (acute myeloid leukemia) patients and is correlated with poor prognosis. In addition, overexpression of IL3RA/CD123 has also been reported for other hematopoietic malignancies . It is considered as a valuable therapeutic target for these malignancies .
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IL3RA polyclonal antibody detects endogenous levels of IL3RA protein.
W4BiowMW: ~ 70 kDa
Reactivity: Human,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human IL3RA.Alternative Name:
Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD_antigen: CD123; IL3RAWestern blot analysis: Western blot (WB) analysis of IL3RA polyclonal antibody at 1:5000 dilution Lane1:H9C2 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:U-87MG whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug)
Immunohistochemistry: Immunohistochemistry of paraffin-embedded Human breast cancer tissue using IL3RA antibody at dilution of 1:20 (x40 lens).
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P26951
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