Product Description
IL18BP polyclonal antibody is available at gentaur for next week delivery
Background: IL-18 (also referred to as IL-1γ) has been shown to augment the secretion of IFN-γ from T lymphocytes and to increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1α and IL-β, respectively, over the twelve β-strands of the β-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1β pro-domain, which must be cleaved by the serine protease ICE for optimal secretion and biological activity. IL-18, which was originally described as IGIF (IFN-γ-inducing factor), IL-18 is induced in mouse liver subsequent to challenge with lipopolysaccharide (LPS). IL-18 binding protein (IL-18BP) functions as an inhibitor of the early Th1 response by binding to IL-18 and inhibiting IFN-γ production. IL-18BP is a member of the immunoglobulin superfamily and shares some homology to IL-1RII.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IL18BP polyclonal antibody detects endogenous levels of IL18BP protein.
W4BiowMW: ~ 38 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human IL18BP.Alternative Name:
Interleukin-18-binding protein; IL-18BP; Tadekinig-alfa; IL18BPWestern blot analysis: Western blot analysis of extracts of various cell lines, using IL18BP antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded mouse heart using IL18BP antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis: Immunofluorescence analysis of A549 cell using IL18BP antibody. Blue: DAPI for nuclear staining.
Host: Rabbit
Swiss-Prot: O95998
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