Product Description
IKBKE polyclonal antibody is available at gentaur for next week delivery
Background: The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKα and IKKβ. IKK-i is primarily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFα, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of IκBα on Ser32 and Ser36, and in NFκB activation, suggesting that IKK-i may act as an IκB kinase in the immune system.
Applications: WB IHC IF IP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IKBKE polyclonal antibody detects endogenous levels of IKBKE protein.
W4BiowMW: ~ 93 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human IKBKE.Alternative Name:
I kappa B kinase epsilon; I-kappa-B kinase epsilon; IkBKE; IKBKE protein; IKK E; IKK i; IKK related kinase epsilon; IKK-E; IKK-epsilon; IKK-i; IKKE; IKKE; IKKepsilon; IKKI; Inducible I kappa B kinase; Inducible I kappa-B kinase; inducible IkappaB kinase; Inhibitor of kappa light polypeptide gene enhancer in B cells kinase epsilon; Inhibitor of nuclear factor kappa B kinase subunit epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; MGC125294; MGC125295; MGC125297Western blot analysis: WesternBlot (WB) analysis of IKBKE polyclonal antibody
Immunohistochemistry:
Immunofluorescence analysis: Immunoprecipitation analysis of 200ug extracts of K-562 cells using 3ug IKBKE antibody.
Host: Rabbit
Swiss-Prot: Q14164
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