Ikaros polyclonal antibody

Product Description

Ikaros polyclonal antibody is available at gentaur for next week delivery

Background: Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).

Applications:  WB IF

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  Ikaros polyclonal antibody detects endogenous levels of Ikaros protein.

W4BiowMW:  ~ 55-75 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Recombinant full length Human Ikaros.

Alternative Name:

DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1; IKZF1; IK1; IKAROS; LYF1; ZNFN1A1

Western blot analysis:  Western blot analysis of Ikaros polyclonal antibody

Immunohistochemistry:

Immunofluorescence analysis: Immunofluorescence analysis of U2OS cells, using Ikaros polyclonal antibody

Host:  Rabbit

Swiss-Prot: Q13422

 

 

 

 

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