Product Description
IGFBP4 polyclonal antibody is available at gentaur for next week delivery
Background: The insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. For instance, IGFBP1 is negatively regulated by insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. It has been suggested that IGFBP2 functions as chaperone, escorting IGFs to their target tissues. It is expressed in several human tissues including fetal eye and fetal brain. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IGFBP4 polyclonal antibody detects endogenous levels of IGFBP4 protein.
W4BiowMW: ~ 17 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human IGFBP4.Alternative Name:
BP 4; BP4; Deb2; HT29 IGFBP; IBP 4; IBP-4; IBP4; IBP4_HUMAN; IGF binding protein 4; IGF-binding protein 4; IGF-BP4; IGFBP 4; IGFBP-4; IGFBP4; Insulin Like Growth Factor Binding Protein 4; Insulin-like growth factor-binding protein 4;Western blot analysis: Western blot analysis of extract of various cells, using IGFBP4 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human liver using IGFBP4 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded human prostate using IGFBP4 antibody at dilution of 1:100 (40x lens).
Host: Rabbit
Swiss-Prot: P22692
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