IGF-IR polyclonal antibody

Product Description

IGF-IR polyclonal antibody is available at gentaur for next week delivery

Background: Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals.

Applications:  WB IHC IF

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  IGF-IR polyclonal antibody detects endogenous levels of IGF-IR protein.

W4BiowMW:  ~ 95,130 kDa

Reactivity: Human,Mouse

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Recombinant full length Human IGF-1R.

Alternative Name:

Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; IGF1R

Western blot analysis:  Western blot analysis of extracts of various cell lines, using IGF1R antibody.

Immunohistochemistry:

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: P08069

 

 

 

 

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