HUMAN CD Antigen designations
| CD antigen | Cellular expression | Molecular weight | Functions | Other names | Family relationships |
|---|---|---|---|---|---|
| CD1a
CD1b CD1c CD1d |
Cortical thymocytes, Langerhans cells, Dendritic cells, B cells (CD1c), Intestinal epithelium (CD1d) | 43-49 | MHC class I-like molecule, associated with b2-microglobulin. May have specialised role in antigen presentation | Ig superfamily (IgSF) | |
| CD2 | T cells, thymocytes, NK cells | 45-58 | Adhesion molecule, binding CD58 (LFA-3). Can activate T cells | T11, LFA-2 | IgSF |
| CD2R | Activated T cells | 45-58 | activation-dependent conformational form of CD2 | T11-3 | IgSF |
| CD3 | Thymocytes, T cells | g:25-28 d:20 e:20 z:16 h:22 |
Associated with the T cell antigen receptor. Required for cell surface expression of and signal transduction by TCR. | T3 | IgSF (gde) z/h related to FcR g chain |
| CD4 | Thymocyte subsets, helper and inflammatory T cells (about two thirds of peripheral T cells), monocytes, macrophages | 55 | Coreceptor for MHC class II molecules. Binds lck on cytoplasmic face of membrane. Receptor for HIV-I and HIV-2 gp120. | T4, L3T4 | IgSF |
| CD5 | Thymocytes, T cells, subset of B cells | 67 | Binds to CD72 | T1, Ly1 | Scavenger receptor |
| CD6 | Thymocytes, T cells, B cell CLL | 100-130 | unknown. | T12 | Scavenger receptor |
| CD7 | Pluripotential hematopoietic cells, thymocytes, T cells | 40 | unknown. Marker for T cell ALL and pluripotential stem cell leukemias | IgSF | |
| CD8 | Thymocyte subsets, cytotoxic T cells (about one third of peripheral T cells) | a: 32-34 b: 32-34 |
Coreceptor for MHC class I molecules. Binds lck on cytoplasmic face of membrane | T8, Lyt2,3 | IgSF |
| CD9 | Pre-B cells, eosinophils, basophils, platelets | 22-27 | possible role in platelet aggregation and activation | tetraspanning membrane protein | |
| CD10 | B and T cell precursors, bone marrow stromal cells | 100 | zinc metalloproteinase, marker for pre B ALL | Neutral endopeptidase, Common Acute Lymphocytic Leukemia Antigen (CALLA) | |
| CD11a | lymphocytes, granulocytes, monocytes and macrophages | 180 | aL subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1), ICAM-2 and ICAM-3 | LFA-1 | |
| CD11b | myeloid and natural killer cells | 170 | aM subunit of integrin CR3 (associated with CD18) ; binds CD54, complement component iC3b and extracellular matrix proteins | Mac-1 | |
| CD11c | myeloid cells | 150 | aX subunit of integrin CR4 (associated with CD18) ; binds fibrinogen | CR4, p150, 95 |
|
| CDw12 | monocytes, granulocytes, platelets | 90-120 | unknown | ||
| CD13 | myelomonocytic cells | 150-170 | zinc metalloproteinase | aminopeptidase N | |
| CD14 | myelomonocytic cells | 53-55 | receptor for complex of LPS and LPS binding protein (LBP) | ||
| CD15
& CD15S |
neutrophils, eosinophils, monocytes | branched pentasaccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM) | Lewsi-x (Lex) | ||
| CD15u | sulphated CD15 | ||||
| CD16
a & b |
neutrophils, NK cells, macrophages | 50-80 | component of low affinity Fc receptor, FcgRIII, mediates phagocytosis and ADCC. | FcgRIII | IgSF |
| CDw17 | neutrophils, monocytes, platelets | lactosyl ceramide, a cell surface glycosphingolipid | |||
| CD18 | Leukocytes | 95 | integrin b2 subunit, associates with CD11a,b and c. | ||
| CD19 | B cells | 95 | forms complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells | IgSF | |
| CD20 | B cells | 33-37 | possible role in regulating B cell activation | tetraspanning membrane protein | |
| CD21 | mature B cells, FDC | 145 | receptor for complement component C3d, EBV. With CD19 and CD81 forms coreceptor for B cells | CR2 | complement control protein (CCP) superfamily |
| CD22 | mature B cells | a: 130 b: 140 |
Adhesion of B cells to monocytes, T cells | BL-CAM | IgSF |
| CD23 | mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets | 45 | low affinity receptor for IgE, ligand for CD19:CD21:CD81 coreceptor | FceRII | C-type lectin |
| CD24 | B cells, granulocytes | 35-45 | unknown | possible human homologue of mouse Heat Stable Antigen (HSA) or J11d. | |
| CD25 | activated T cells, B cells, monocytes | a:55 :b75 |
IL-2 receptor | Tac | a:CCP b: cytokine receptor superfamily |
| CD26 | Activated B and T cells, macrophages | 110 | protease. Recently implicated in HIV entry into cells. | Dipeptidyl peptidase IV | |
| CD27 | Medullary thymocytes, T cells | 50-55 | unknown | NGF receptor superfamily | |
| CD28 | T cell subsets, activated B cells | 44 | Activation of naive T cells, receptor for costimulatory signal (signal 2) binds CD80 (B7-1) and B7-2 | Tp44 | IgSF |
| CD29 | Leukocytes | 130 | Integrin b1 subunit, associates with CD49a in VLA-1 integrin | ||
| CD30 | Activated B and T cells | 105-120 | unknown | Ki-1 | NGF receptor superfamily |
| CD31 | monocytes, platelets, granulocytes, B cells, endothelial cells | 130-140 | Possibly an adhesion molecule | PECAM-1 | IgSF |
| CDw32 | Monocytes, granulocytes, B cells eosinophils | 40 | low affinity Fc receptor for aggregated Ig/immune complexes | FcgRII | IgSF |
| CD33 | myeloid progenitor cells, monocytes | 67 | unknown | IgSF | |
| CD34 | hematopoietic precursors, capillary endothelium | 105-120 | Ligand for CD62 (L-selectin) | ||
| CD35 | Erythrocytes, B cells, monocytes, neutrophils, eosinophils, FDC | 250 | Complement receptor 1, binds C3B and C4b, mediates phagocytosis | CR1 | CCP superfamily |
| CD36 | platelets, monocytes | 88 | unknown | platelet GPIV | |
| CD37 | mature B cells, mature T cells, myeloid cells | 40-52 | unknown | tetraspanning membrane protein | |
| CD38 | early B and T cells, activated T cells, germinal centre B cells, plasma cells | 45 | unknown | ||
| CD39 | activated B cells, activated NK cells, macrophages, dendritic cells | 78 | unknown, may mediate adhesion of B cells | ||
| CD40 | B cells, monocytes, dendritic cells | 50 | receptor for costimulatory signal for B cells, binds CD40 Ligand (T-BAM), | NGF receptor superfamily | |
| CD40L (CD154) | activated CD4 T cells | 39 | ligand for CD40, | T-BAM | TNF-like |
| CD41 | platelets, megakaryocytes | 125/22 dimer | aIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor and thrombospondin | ||
| CD42a
, b, c, d |
platelets, megakaryocytes | a: 23 b: 135, 23 c: 22 d: 85 |
binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury | a: GPIX b: GPIba c: GPIbb d: GPV |
|
| CD43 | leukocytes, except resting B cells | 115-135 (neutrophils) 95-115 (T cells) |
binds CD54 (ICAM-1) | leukosialin, sialophorin | |
| CD44 | leukocytes, erythrocytes | 80-95 | binds hyaluronic acid, mediates adhesion of leukocytes | Hermes antigen, Pgp-1 | |
| CD45 | leukocytes | 180-240 | tyrosine phosphatase, augments signalling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below) | Leukocyte common antigen (LCA), T200, B220 | |
| CD45RO | T cell subsets, B cell subsets, monocytes, macrophages | 180 | isoform of CD45 containing none of the A, B and C exons | ||
| CD45RA | B cells, T cell subsets (naive T cells) monocytes | 205-220 | isoforms of CD45 containing the A exon | ||
| CD45RB | T cell subsets, B cells, monocytes, macrophages, granulocytes | 190-220 | isoforms of CD45 containing the B exon | T200 | |
| CD45RC | Restricted T200 | ||||
| CD46 | hematopoietic and non-hematopoietic nucleated cells | 56/66 (splice variants) | membrane cofactor protein, binds to C3b and C4b to permit their degradation by Factor I | MCP | CCP superfamily |
| CD47 | all cells | 47-52 | unknown, associated with Rh blood group | ||
| CD47R | previously CDw149 | ||||
| CD48 | leukocytes | 40-47 | unknown | Blast-1 | IgSF |
| CD49a | activated T cells, monocytes | 210 | a1 integrin, associates with CD29, binds collagen, laminin | VLA-1 | |
| CD49b | B cells, monocyte, platelets | 165 | a2 integrin, associates with CD29, binds collagen, laminin | VLA-2 | |
| CD49c | B cells | 125 | a3 integrin, associates with CD29, bindslaminin, fibronectin | VLA-3 | |
| CD49d | B cells, thymocytes | 150 | a4 integrin, associates with CD29, binds fibronectin, PeyerÕs Patch HEV, VCAM-1 | VLA-4 | |
| CD49e | memory T cells, monocytes, platelets | 135, 25 dimer | a5 integrin, associates with CD29, binds fibronectin | VLA-5 | |
| CD49f | memory T cells, thymocytes, monocytes | 120, 25 dimer | a6integrin, associates with CD29, binds laminin | VLA-6 | |
| CD50 | thymocytes, T cells, B cells,monocytes, granulocytes | 130 | unknown | ICAM3 | |
| CD51 | platelets, megakaryocytes | 125,24 dimer | av integrin, associates with CD61, binds vitronectin, von Willebrand factor, fibrinogen and thrombospondin | vitronectin receptor | |
| CD52 | thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes | 21-28 | unknown, target for antibodies used therapeutically to deplete T cells | CAMPATH-1 | |
| CD53 | leukocytes | 35-42 | unknown | MRC OX44 | tetraspanning membrane protein |
| CD54 | hematopoietic and non-hematopoietic cells | 85-110 | InterCellular Adhesion Molecule, (ICAM)-1 binds CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) integrins, receptor for rhinovirus | ICAM-1 | IgSF |
| CD55 | hematopoietic and non-hematopoietic cells | 60-70 | Decay Accelerating Factor (DAF), binds C3b, disassembles C3/C5 convertase | DAF | CCP superfamily |
| CD56 | NK cells | 175-185 | isoform of Neural Cell Adhesion Molecule (NCAM), adhesion molecule | NKH-1 | IgSF |
| CD57 | NK cells subsets of T cells, B cells and monocytes | oligosaccharide, found on many cell surface glycoproteins | HNK-1, Leu-7 | ||
| CD58 | hematopoietic and non-hematopoietic cells | 55-70 | Leukocyte Function-associated Antigen-3 (LFA-3), binds CD2, adhesion molecule | LFA-3 | IgSF |
| CD59 | hematopoietic and non-hematopoietic cells | 19 | binds comlement components C8 and C9, blocks assembly of membrane attack complex | Protectin, Mac inhibitor | |
| CD60 | T cell subsets, platelets, monocytes | oligosaccharide present on gangliosides | |||
| CD60a | GD3 | ||||
| CD60b | 9-O-acetyl-GD3 | ||||
| CD60c | 7-O-acetyl-GD3 | ||||
| CD61 | platelets, megakaryocytes, macrophages | 105 | integrin b3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin receptor) | ||
| CD62E | endothelium | 140 | endothelium leukocyte adhesion molecule (ELAM), bindssialyl-Lewis x, mediates rolling interaction of neutrophils on endothelium | ELAM-1, E-selectin | C type lectin |
| CD62L | B cells, T cells, monocytes, NK cells | 150 | leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling interactions with endothelium | LAM-1, L-selectin, LECAM-1 | C type lectin |
| CD62P | platelets, megakaryocytes, endothelium | 140 | adhesion molecule, binds sialyl Lewis x, mediates interaction of platelets with neutrophils, monocytes and rolling interaction of neutrophils on endothelium | P-selectin, PADGEM | C type lectin |
| CD63 | activated platelets, monocytes, macrophages | 53 | unknown, is lysosomal membrane protein translocated to cell surface after activation | tetraspanning membrane protein | |
| CD64 | monocytes, macrophages | 72 | hign affinity receptor for IgG | FcgRI | IgSF |
| myeloid cells | oligosaccharide component of a ceramide dodecasaccharide | ||||
| CD65 | Ceramide dodecasaccharide 4c | ||||
| CD66a | neutrophils | 160-180 | unknown, member of carcinoembryonic antigen (CEA) family (see below) | biliary glycoprotein-1 (BGP-1) | IgSF |
| CD66b | granulocytes | 95-100 | unknown, member of carcinoembryonic antigen (CEA) family | previously CD67 | IgSF |
| CD66c | neutrophils, colon carcinoma | 90 | unknown, member of carcinoembryonic antigen (CEA) family | Nonspecific Crossreacting Antigen (NCA) | IgSF |
| CD66d | neutrophils | 30 | unknown, member of carcinoembryonic antigen (CEA) family | IgSF | |
| CD66e | adult colon epithelium, colon carcinoma | 180-200 | unknown, member of carcinoembryonic antigen (CEA) family | CarcinoEmbryonic Antigen (CEA) | IgSF |
| CD66f | Pregnancy specific glycoprotein | ||||
| CD68 | monocytes, macrophages, neutrophils, basophils, large lymphocytes | 110 | unknown | macrosialin | |
| CD69 | activated B cells, activated T cells, activated macrophages, activated NK cells | 28, 32 homodimer | unknown, early activation antigen | Activation Inducer Molecule (AIM) | |
| CD70 | activated B cells, activated T cells, macrophages | 75,95,170 | unknown | Ki-24 | |
| CD71 | activated leukocytes | 90-95 homodimer | transferrin receptor | T9 | |
| CD72 | B cells | 42 homodimer | unknown, ligand for CD5 | Lyb-2 | C type lectin |
| CD73 | B cell subsets, T cell subsets | 69 | ecto-5Õ-nucleotidase, dephosphorylates nucleotides to allow nucleoside uptake | ||
| CD74 | B cells, macrophages, monocytes, MHC class II positive cells | 33,35,41,43 (alternate initiation and splicing) | MHC class II associated Invariant chain | Ii, Ig | |
| CD75 | mature B cells, T cell subsets | unknown, possibly oligosaccharide, dependent on sialylation | |||
| CDw76
CD75s |
alpha-2,6-sialylated
lactosamines |
unknown, possibly oligosaccharide, dependent on sialylation | |||
| CD77 | germinal center B cells | unknown, | Globotriaocylceramide (Gb3), Pk blood group | ||
| CDw78
(deleted) |
B cells | unknown | Ba | ||
| CD79a,
CD79b |
B cells | a: 32-33 b: 37-39 |
components of B cell antigen receptor analogous to CD3, required for cell surface expression and signal transduction | Iga, Igb | IgSF |
| CD80 | B cell subset | 60 | costimulator, ligand for CD28 and CTLA-4 | B7 (now B7-1), BB1 | IgSF |
| CD81 | lymphocytes | 26 | associates with CD19, CD21 to form B cell coreceptor | Target of AntiProliferative Antibody (TAPA-1) | tetraspanning membrane protein |
| CD82 | leukocytes | 50-53 | unknown | R2 | tetraspanning membrane protein |
| CD83 | Activated B cells, activated T cells, circulating dendritic cells (veil cells) | 43 | HB15 | ||
| CDw84 | monocytes, platelets, circulating B cells | 73 | GR6 | ||
| CD85 | ILT/LIR family | ||||
| CD86 | monocytes, activated B cells | 80 | FUN-1, GR65 | ||
| CD87 | granulocytes, monocytes, macrophages, activated T cells | 50-65 | Urokinase plasminogen activator receptor | UPA-R | |
| CD88 | polymorphonuclear leukocytes, macrophages, mast cells | 40 | Receptor for complement component C5a | C5aR | rhodopsin superfamily |
| CD89 | monocytes, macrophages, granulocytes, neutrophils, B cell subsets, T cell subsets | 50-70 | IgA receptor | FcaR | IgSF |
| CD90 | CD34+ prothymocytes (human) thymocytes, T cells (mouse) | 18 | unknown | Thy-1 | IgSF |
| CD91 | monocytes | 600 | a2 macroglobulin receptor see lipoprotein | unknown | |
| CDw92 | neutrophils, monocytes, platelets, endothelium | 70 | unknown | GR9 | |
| CD93 | neutrophils, monocytes, endothelium | 120 | unknown | GR11 | |
| CD94 | T cell subsets, NK cells | 43 | unknown | KP43 | |
| CD95 | wide variety of cell lines in vivodistribution uncertain | 43 | binds TNF-like ligand, induces apoptosis | Apo-1, Fas | NGF receptor superfamily |
| CD96 | activated T cells | 160 | Unknown | T cell ACTivation Increased Late Expression (TACTILE) | |
| CD97 | activated cells | 74, 80, 90 | unknown | GR1 | |
| CD98 | T cells, B cells, NK cells, granulocytes, all human cell lines | 80, 40 heterodimer | unknown | 4F2 | |
| CD99 | Peripheral blood lymphocytes, thymocytes | 32 | Unknown | MIC2, E2 | |
| CD100 | Broad expression on haematopoietic cells | 150 | unknown | GR3 | |
| CD101 | Granulocytes, macrophages | 140 | Unknown | BPC#4,BB27;BA27 | |
| CD102 | Resting lymphocytes, monocytes, strongest on vascular endothelial cells | 55-65 | binds CD11a/CD18 (LFA-1) but not CD11b/CD18 (Mac-1) | ICAM-2 | IgSF |
| CD103 | Intraepithelial lymphocytes, 2-6% of peripheral blood lymphocytes | 150,25 | aE integrin | HML-1, a6, aE integrin | |
| CD104 | Epithelia, Schwann cells, some tumour cells | 220 | b4 integrin | b4, b4 integrin | |
| CD105 | Endothelial cells, bone marrow cell subset, in vitro activated macrophages | 95, homodimer | unknown, possibly ligand for an integrin | Endoglin | |
| CD106 | Endothelial cells | 100,110 | Adhesion molecule, ligand for VLA-4 | VCAM-1 | IgSF |
| CD107a | Activated platelets | 110 | Unknown, is lysosomal membrane protein translocated to the cell surface after activation | Lysosomal Associated Membrane Protein-1 (LAMP-1) | |
| CD107b | activated platelets | 120 | Unknown, is lysosomal membrane protein translocated to the cell surface after activation | LAMP-2 | |
| CD108 | Activated T cells in spleen, some stromal cells | 80 | Unknown | GR2 | |
| CD109 | Activated T cells, platelets, endothelial cells | 170/50 | Unknown | Platelet activation factor, GR56 | |
| CD110 | Platelets | NPL, TPO R | |||
| CD111 | Myeloid Cells | PRR1/Nectin1 | |||
| CD112 | Myeloid Cells | PRR2 |