Product Description
HP1 alpha (Phospho-S92) polyclonal antibody is available at gentaur for next week delivery
Background: Heterochromatin protein 1 (HP1) is a family of heterochromatic adaptor molecules involved in both gene silencing and higher order chromatin structure. All three HP1 family members (α, β, and γ) are primarily associated with centromeric heterochromatin; however, HP1β and γ also localize to euchromatic sites in the genome. HP1 proteins are approximately 25 kDa in size and contain a conserved amino-terminal chromodomain, followed by a variable hinge region and a conserved carboxy-terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 tri-methylated at Lys9, a histone "mark" closely associated with centromeric heterochromatin.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: HP1 alpha (Phospho-S92) polyclonal antibody detects endogenous levels of HP1 alpha protein only when phosphorylated at Ser92.
W4BiowMW: ~ 25 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic phosphopeptide derived from human HP1 alpha around the phosphorylation site of Serine 92.Alternative Name:
Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha; HP1α; CBX5; HP1AWestern blot analysis: Western blot (WB) analysis of HP1 alpha (Phospho-S92) polyclonal antibody at 1:500 dilution LaneA:PC3 whole cell lysate LaneB:The Heart tissue lysate of Mouse LaneC:The Brain tissue lysate of Mouse LaneD:The Heart tissue lysate of Rat
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P45973
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