Product Description
HDAC4 polyclonal antibody is available at gentaur for next week delivery
Background: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, p300/CBP, PCAF (p300/CBPassociated factor), HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: HDAC4 polyclonal antibody detects endogenous levels of HDAC4 protein.
W4BiowMW: ~ 130 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human HDAC4.Alternative Name:
Histone deacetylase 4; HD4; HDAC4; KIAA0288Western blot analysis: Western blot analysis of extracts of various cell lines, using HDAC4 antibody.
Immunohistochemistry: Immunohistochemistry (IHC) analysis of HDAC4 pAb in paraffin-embedded H-lung tissue.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P56524
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