Product Description
HDAC1 polyclonal antibody is available at gentaur for next week delivery
Background: Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
Applications: WB IHC IF IP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: HDAC1 polyclonal antibody detects endogenous levels of HDAC1 protein.
W4BiowMW: ~ 62 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human HDAC1.Alternative Name:
Histone deacetylase 1; HD1; RPD3L1Western blot analysis: Western blot analysis of extracts of various cell lines, using HDAC1 antibody.
Immunohistochemistry: Immunohistochemistry (IHC) analysis of HDAC1 pAb in paraffin-embedded Pancreas cancer tissue.
Immunofluorescence analysis: Immunoprecipitation analysis of 200ug extracts of HT-29 cells, using 3 ug HDAC1 antibody.
Host: Rabbit
Swiss-Prot: Q13547
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