Product Description
GRK 3 /ADRBK2 polyclonal antibody is available at gentaur for next week delivery
Background: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ADRBK2 polyclonal antibody detects endogenous levels of ADRBK2 protein.
W4BiowMW: ~ 100 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human GRK 3.Alternative Name:
G-protein coupled receptor kinase 3; Beta-adrenergic receptor kinase 2; Beta-ARK-2; GRK3; BARK2;Western blot analysis: Western blot analysis of GRK 3 /ADRBK2 polyclonal
Immunohistochemistry: Immunohistochemistry (IHC) analysis of GRK 3 /ADRBK2 polyclonal in paraffin-embedded Human Kidney Cancer tissue.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P35626
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